All patients starting therapy with Lipitor should be advised of the risk of myopathy and told to report promptly any unexplained muscle pain, tenderness, or weakness. Aluminum Hydroxide; Magnesium Carbonate: Moderate Concomitant administration of atorvastatin with antacids reduced the plasma concentrations of atorvastatin by approximately 35 percent. Never try to catch up by taking two doses at once. If you are experiencing weight gain or anxiety, you may want to contact your doctor to determine the cause. This raises your risk for muscle breakdown.
Raltegravir: Moderate Raltegravir use has been associated with elevated creatinine kinase concentrations; myopathy and rhabdomyolysis have been reported. Patients undergoing combined therapy should be carefully monitored for myopathy or rhabdomyolysis, particularly in the early months of treatment or during periods of upward dose titration of either drug. Monitor patients for any signs or symptoms of muscle pain, weakness, or tenderness especially in the initial months of therapy and any time the dosage of either drug is titrated upward. If treatment with posaconazole is unavoidable, a brief suspension of atorvastatin therapy can be considered. Enzalutamide: Major Monitor for decreased efficacy of atorvastatin if coadministration with enzalutamide is necessary. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.
Always to speak with your doctor or pharmacist about dosages that are right for you. Coadministration of certain drugs with atorvastatin may need to be avoided or dosage adjustments may be necessary; review drug interactions. The listed side effects occurred at greater than a 10 percent incidence in patients studied during clinical trials. In rare cases, Lipitor can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Ethinyl Estradiol; Norethindrone; Ferrous fumarate: Minor Atorvastatin can increase the plasma concentrations of oral contraceptives when the drugs are coadministered. Pioglitazone: Minor Concentrations of atorvastatin may be decreased with concomitant use of pioglitazone. If evidence of serious liver injury occurs while a person is taking atorvastatin, it should be discontinued and not restarted until the etiology of the person's liver dysfunction is defined.
Myoglobin in the blood is harmful to the kidney and can cause kidney damage. The clinical significance of this theoretical interaction is not known. Lipitor has not been studied in controlled clinical trials involving pre-pubertal patients or patients younger than 10 years of age. This may raise your risk for heart attack or stroke. Antifungal medications, birth control pills, and other cholesterol-inhibiting medications should especially be noted.
Could my liver have been affected from all those years of Lipitor? A: The effects of Lipitor atorvastatin on sexual function in women is unknown, but there are reports of erectile dysfunction in men taking Lipitor. The black cohosh dose is above that usually recommended for dietary supplementation, and cases of hepatotoxicity have been reported with black cohosh alone. Regarding wine, one drink is five ounces. Lipitor can lower the risk for heart attack or stroke in patients with diabetes and risk factors such as diabetic eye or kidney problems, smoking, or high blood pressure. Doctors may increase dosages gradually. Feel free to visit our informational page for more:. Liver function tests should be measured prior to the initiation of therapy of Lipitor atorvastatin and again at twelve weeks of therapy.
However, you should not flush this medication down the toilet. After administration, fosaprepitant is rapidly converted to aprepitant and shares many of the same drug interactions. Coadministration may increase the plasma concentrations of atorvastatin. Increased concentrations of the statins increases the risk for myopathy and other statin-related side effects. Talk to your doctor about any worsening or bothersome side effects. Taking these drugs together increases the plasma concentrations of atorvastatin.
Aluminum Hydroxide; Magnesium Hydroxide; Simethicone: Moderate Concomitant administration of atorvastatin with antacids reduced the plasma concentrations of atorvastatin by approximately 35 percent. Lipitor works to reduce the amount of cholesterol that is made by the liver. This is not a complete list of side effects and others may occur. Other variables associated with an increased risk of statin-induced myopathy include, advanced age, small body stature, female gender, pre-existing kidney or liver dysfunction, hypothyroidism, diabetes, recent surgery, and alcoholism. If these drugs are coadministered, carefully monitor the patient. Grapefruit and grapefruit juice may interact with Lipitor atorvastatin and lead to serious side effects.
By 2003 Lipitor had become the best selling pharmaceutical in the United States. The ortho-hydroxy metabolite undergoes further metabolism via. Amoxicillin; Clarithromycin; Omeprazole: Major Do not exceed 20 mg per day of atorvastatin daily if coadministration with clarithromycin cannot be avoided. These increases should be considered when administering atorvastatin and oral contraceptives concomitantly. It is not intended to be a substitute for the exercise of professional judgment.
The symptoms were not serious, and they were rare and reversible on cessation of treatment with the medication. Reduce digoxin concentrations by decreasing the digoxin dose by approximately 15-30% or by modifying the dosing frequency and continue monitoring. The most common side effects with Lipitor are headache, dyspepsia upset stomach , diarrhea, alterations of some laboratory tests. This can be harmful or prevent the drug from working well. Area-under-the-curve values for norethindrone and ethinyl estradiol were increased by approximately 30% and 20%, respectively, when atorvastatin was given concurrently.
Patients receiving these agents concurrently should be monitored for myotoxicity. Sodium Bicarbonate: Moderate Concomitant administration of atorvastatin with antacids reduced the plasma concentrations of atorvastatin by approximately 35 percent. Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide: Major Avoid concurrent administration of atorvastatin with cobicistat. Grapefruit juice: Major Grapefruit juice should be avoided in patients taking atorvastatin to avoid the potential for drug accumulation and toxicity i. Alcohol interaction warning The use of drinks that contain alcohol raises your risk for liver disease from atorvastatin. After several weeks, your healthcare provider will likely recommend that you have your checked once again. Stop taking the statin and call your physician if you notice any muscle pain, tenderness, or weakness; nausea; stomach pain; low fever; loss of appetite; dark urine; clay-colored stools; or jaundice yellowing of the skin or eyes.